3-Hydroxy Carvedilol

Base Information

Chemical Name:3-Hydroxy Carvedilol
CAS No.:146574-43-8
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:
DSSTox Substance ID:DTXSID20932859
Nikkaji Number:J524.739J
ChEMBL ID:CHEMBL3741650
Mol file:146574-43-8.mol

Synonyms:(4-(2-hydroxy-3-((2-(2-methoxy-phenoxy)ethyl)amino)propoxyl)-9H-carbazol-3-ol);SB 211475;SB-211475

Suppliers and Price of 3-Hydroxy Carvedilol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-HydroxyCarvedilol
25mg
$ 4555.00

TRC
3-HydroxyCarvedilol
5mg
$ 1090.00

TRC
3-HydroxyCarvedilol
1mg
$ 250.00

Total 12 raw suppliers

Chemical Property of 3-Hydroxy Carvedilol

Chemical Property:

Vapor Pressure:1.1E-20mmHg at 25°C
Boiling Point:702°C at 760 mmHg
Flash Point:378.3°C
PSA：95.97000
Density:1.305g/cm³
LogP:3.83450
XLogP3:3.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:422.18417193
Heavy Atom Count:31
Complexity:538

Purity/Quality:

99% ^*data from raw suppliers

3-HydroxyCarvedilol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1OCCNCC(COC2=C(C=CC3=C2C4=CC=CC=C4N3)O)O
Uses A vascularly inactive metabolite of Carvedilol (C184625). A novel antihypertensive agent, is a potent antioxidant.

Technology Process of 3-Hydroxy Carvedilol

There total 3 articles about 3-Hydroxy Carvedilol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: C₁₅H₁₃NO₃

: 146574-43-8
1-[3-hydroxycarbazolyl-⁽⁴⁾-oxy]-3-[2-(2-methoxyphenoxy)ethylamino]propanol-⁽²⁾

Guidance literature:: In isopropyl alcohol; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2015.11.008

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 146574-43-8
1-[3-hydroxycarbazolyl-⁽⁴⁾-oxy]-3-[2-(2-methoxyphenoxy)ethylamino]propanol-⁽²⁾

Guidance literature:: Multi-step reaction with 3 steps

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h

3: isopropyl alcohol / 18 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.11.008

Reference yield:

: 51997-51-4,95093-96-2
4-(2,3-epoxypropoxy)carbazole

: 146574-43-8
1-[3-hydroxycarbazolyl-⁽⁴⁾-oxy]-3-[2-(2-methoxyphenoxy)ethylamino]propanol-⁽²⁾

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h

2: isopropyl alcohol / 18 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.11.008