methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

Base Information

Chemical Name:methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate
CAS No.:1334608-13-7
Molecular Formula:C₂₈H₃₀N₄O₃
Molecular Weight:470.571
Hs Code.:

Synonyms:methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

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Chemical Property of methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

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Technology Process of methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

There total 5 articles about methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334608-12-6
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-[(1-methylethyl)oxy]benzonitrile

: 343238-58-4
methyl azetidine-3-carboxylate

: 1334608-13-7
methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

Guidance literature:: 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-[(1-methylethyl)oxy]benzonitrile; methyl azetidine-3-carboxylate; With sodium acetate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 40530-18-5
5-bromo-2-hydroxybenzonitrile

: 1334608-13-7
methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 48 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

5.1: sodium acetate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 2 h / 20 °C

With potassium phosphate; potassium acetate; sodium acetate; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 515832-52-7
5-bromo-2-[(1-methylethyl)oxy]benzonitrile

: 1334608-13-7
methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: sodium acetate / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C

With potassium phosphate; potassium acetate; sodium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;