(S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

Base Information

• Chemical Name: (S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine
• CAS No.: 151223-25-5
• Molecular Formula: C₄₉H₅₄N₅O₇P
• Molecular Weight: 855.971

Synonyms:(S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

Chemical Property of (S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

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Technology Process of (S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

There total 1 articles about (S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine (151223-24-4) + mono-4-methoxytrityl chloride (14470-28-1) → (S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N2-<(p-methoxyphenyl)diphenylmethyl>guanine (151223-25-5)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 20h;

DOI:10.1021/jm00071a003

Reference yield: 51.0%

(S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N2-<(p-methoxyphenyl)diphenylmethyl>guanine (151223-25-5) → (S)-9-<3-hydroxy-2-<(diisopropylphosphono)methoxy>propyl>-N2-<(p-methoxyphenyl)diphenylmethyl>guanine (151223-26-6)

Guidance literature:

With cyclohexene; palladium dihydroxide; In ethanol; for 14h; Heating;

DOI:10.1021/jm00071a003

Reference yield:

(S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N2-<(p-methoxyphenyl)diphenylmethyl>guanine (151223-25-5) → (S)-9-<3-chloro-2-<(diisopropylphosphono)methoxy>propyl>-N2-<(p-methoxyphenyl)diphenylmethyl>guanine

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / cyclohexene / 20percent Pd(OH)2/C / ethanol / 14 h / Heating

2: 0.68 g / CCl₄, Ph₃P, imidazole, pyridine / acetonitrile / 17 h / 20 - 80 °C

With pyridine; 1H-imidazole; tetrachloromethane; triphenylphosphine; cyclohexene; palladium dihydroxide; In ethanol; acetonitrile;

DOI:10.1021/jm00071a003

upstream raw materials:

(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

mono-4-methoxytrityl chloride

Downstream raw materials:

(S)-9-<3-hydroxy-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

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