2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

Base Information

Chemical Name:2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol
CAS No.:511546-67-1
Molecular Formula:C₁₈H₃₁NO₄Si
Molecular Weight:353.534
Hs Code.:

Synonyms:2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

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Chemical Property of 2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

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Technology Process of 2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

There total 4 articles about 2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 511546-66-0
allyl (2S)-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butanoate

: 511546-67-1
2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 7h;
DOI:10.1021/jo026776v

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 511546-67-1
2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / aq. NaHCO₃ / 24 h / 20 °C

2.1: NaOH / H₂O; ethanol / 24 h / 20 °C

2.2: 96 percent / dimethylformamide / 48 h / 20 °C

3.1: 85 percent / pyridine / 4 h / 0 °C

4.1: 81 percent / LiBH₄ / tetrahydrofuran / 7 h / 0 - 20 °C

With pyridine; sodium hydroxide; lithium borohydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo026776v

Reference yield:

: 35677-88-4
N-benzyloxycarbonyl-(L)-homoserine

: 511546-67-1
2S-2-(benzyloxycarbonyl)amino-4-[(tert-butyldimethylsilyl)oxy]butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOH / H₂O; ethanol / 24 h / 20 °C

1.2: 96 percent / dimethylformamide / 48 h / 20 °C

2.1: 85 percent / pyridine / 4 h / 0 °C

3.1: 81 percent / LiBH₄ / tetrahydrofuran / 7 h / 0 - 20 °C

With pyridine; sodium hydroxide; lithium borohydride; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo026776v