8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate

Base Information

• Chemical Name: 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate
• CAS No.: 1264221-48-8
• Molecular Formula: C₃₁H₄₀FN₃O₇Si
• Molecular Weight: 613.758
• Mol file: 1264221-48-8.mol

Synonyms:8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate

Chemical Property of 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate

There total 23 articles about 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

C31H42FN3O8Si (1264241-26-0) → 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate (1264221-48-8)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 24h;

Reference yield: 61.0%

C32H33FN4O10 → 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate (1264221-48-8)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 22h;

Reference yield:

(2S,4S)-allyl 2-(hydroxymethyl)-4-((2-(trimethylsilyl)ethoxy)carbonylamino)pyrrolidine-1-carboxylate (1264239-29-3) → 8-benzyl 2-[2-(trimethylsilyl)ethyl] (2S,8S,16aS)-12-fluoro-8-methyl-5,10-dioxo-2,3,5,6,7,8,9,10,16,16a-decahydro-1H-pyrrolo-[2,1-c][1,4,9]benzoxadiazacyclododecine-2,8-dicarboxylate (1264221-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,1'-azodicarbonyl-dipiperidine; triphenylphosphine / chloroform / 16 h / 0 - 20 °C / Inert atmosphere

2: 1,3-dimethylbarbituric acid / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; ethyl acetate / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 22 h / 20 °C

With 1,3-dimethylbarbituric acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; chloroform; ethyl acetate;

upstream raw materials:

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

benzyl bromide

(2S,4S)-allyl 2-(hydroxymethyl)-4-((2-(trimethylsilyl)ethoxy)carbonylamino)pyrrolidine-1-carboxylate

N-α-(t-butoxycarbonyl)-L-glutamic γ-allyl ester