(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester
CAS No.:906079-95-6
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

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Chemical Property of (4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

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Technology Process of (4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

There total 6 articles about (4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 227023-81-6
3-benzyloxy-5-ethoxy-benxaldehyde

: 906079-95-6
(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 2 h / 20 °C

2: BF₃*Et₂O / 1 h / 20 °C

3: 49.1 g / water / ethanol / Heating

4: 67 percent / H₂ / Pd-C / ethanol; tetrahydrofuran / 5 h / 20 °C

5: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 5 h

With boron trifluoride diethyl etherate; water; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 5: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: 871345-30-1
(3-benzyloxy-5-ethoxy-phenyl)-(4-cyano-phenylamino)-acetic acid methyl ester

: 906079-95-6
(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / H₂ / Pd-C / ethanol; tetrahydrofuran / 5 h / 20 °C

2: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 5 h

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: CH₃CH₂OC₆H₅CH₂OC₆H₃CHNHC₆H₄CNCOCH₃NCH₂C₆H₄SO₂CH₃

: 906079-95-6
(4-cyano-phenylamino)-[3-ethoxy-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 49.1 g / water / ethanol / Heating

2: 67 percent / H₂ / Pd-C / ethanol; tetrahydrofuran / 5 h / 20 °C

3: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 5 h

With water; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; 3: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.03.042