5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

Base Information

Chemical Name:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid
CAS No.:1093631-47-0
Molecular Formula:C₂₉H₂₅Cl₂NO₄
Molecular Weight:522.428
Hs Code.:

Synonyms:5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

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Chemical Property of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

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Technology Process of 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

There total 5 articles about 5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₂₇Cl₂NO₄

: 1093631-47-0
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

Guidance literature:: C₃₀H₂₇Cl₂NO₄; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 628732-09-2
methyl 5-bromo-2,3-dihydro-1H-indene-2-carboxylate

: 1093631-47-0
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 6 h / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 50 °C

With potassium phosphate; water; potassium carbonate; triphenylphosphine; sodium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 583-71-1
4-bromo-o-xylene

: 1093631-47-0
5-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2,3-dihydro-1H-indene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 22 h / 80 °C

1.2: 16.5 h / 20 °C

2.1: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 6 h / 90 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

4.1: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 50 °C

With potassium phosphate; N-Bromosuccinimide; water; potassium carbonate; triphenylphosphine; sodium hydroxide; dibenzoyl peroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;