(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:166047-51-4
Molecular Formula:C₂₃H₂₉N₇O₅
Molecular Weight:483.527
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Suppliers and Price of (S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

There total 4 articles about (S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (S)-2-(4-{[1-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-meth-(E)-ylidene]-amino}-benzoylamino)-pentanedioic acid diethyl ester

: 166047-51-4
(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; for 4h; Ambient temperature;
DOI:10.1021/jm00012a016

Reference yield:

: 98130-58-6
2-amino-5-bromo-1H-pyrrole-3,4-dicarbonitrile

: 166047-51-4
(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / H₂ / 5percent Pd/BaCO₃ / methanol / 3 h / 2585.7 Torr

2: 48 h / 160 - 170 °C

3: 50 percent / H₂ / Raney Ni / aq. acetic acid / 24 h / Ambient temperature

4: 50 percent / NaCNBH₃, HCl / methanol / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; palladium-barium carbonate; nickel; In methanol; acetic acid;
DOI:10.1021/jm00012a016

Reference yield:

: 77446-35-6
2-amino-3,4-dicyanopyrrole

: 166047-51-4
(S)-2-{4-[(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 48 h / 160 - 170 °C

2: 50 percent / H₂ / Raney Ni / aq. acetic acid / 24 h / Ambient temperature

3: 50 percent / NaCNBH₃, HCl / methanol / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium cyanoborohydride; nickel; In methanol; acetic acid;
DOI:10.1021/jm00012a016