(2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid

Base Information

• Chemical Name: (2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid
• CAS No.: 1138323-75-7
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.309
• Mol file: 1138323-75-7.mol

Synonyms:(2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid

Chemical Property of (2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Cbz-(R)-2-(aminomethyl)-3-methylbutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid

There total 1 articles about (2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

C21H28N2O5 → (2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid (1138323-75-7)

Guidance literature:

C₂₁H₂₈N₂O₅; With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

With sodium sulfite; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetasy.2008.12.023

Reference yield: 70.0%

(2R)-([{(benzyloxy)carbonyl}amino]methyl)-3-methylbutanoic acid (1138323-75-7) → (2R)-([amino]methyl)-3-methylbutanoic acid (210345-86-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 4h; under 760.051 Torr; enantioselective reaction;

DOI:10.1016/j.tetasy.2008.12.023

Downstream raw materials:

(2R)-([amino]methyl)-3-methylbutanoic acid