(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

Base Information

Chemical Name:(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one
CAS No.:80664-34-2
Molecular Formula:C₃₂H₃₂N₂O₄S₂
Molecular Weight:572.749
Hs Code.:

Synonyms:(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

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Chemical Property of (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

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Technology Process of (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

There total 5 articles about (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 80664-33-1
Trifluoro-acetic acid 2-[(4aS,11cR)-4a-ethyl-7-(4-methoxy-benzenesulfonyl)-2-oxo-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-1-phenylsulfanyl-ethyl ester

: 80664-34-2
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

Guidance literature:: In chlorobenzene; at 130 ℃; for 2.5h;
DOI:10.1021/ja00368a058

Reference yield:

: 80664-29-5
cis-4a-ethyl-1,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1-<2-(phenylthio)ethyl>-2H-pyrido<3,2-c>carbazol-2-one

: 80664-34-2
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / aq. sodium bicarbonate, m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.83 h / 0 °C

2: 1.) trifluoroacetic anhydride / 1.) methylene chloride, 0 deg C₁₀ min; 0 deg c -> 20 deg C, 30 min; 2.) chlorobenzene, 20 deg C -> 135 deg C, 1.5 h; 135 deg C, 2.5 h

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/ja00352a038

Reference yield:

: 2014-75-7
2-(phenylthio)ethanamine

: 80664-34-2
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(phenylthio)-aspidospermidin-8-one

Guidance literature:: Multi-step reaction with 5 steps

2: 33 percent / chlorobenzene / 2.75 h / 140 °C

3: 97 percent / MCPBA, NaHCO₃ / CH₂Cl₂ / 0 °C

4: CH₂Cl₂ / 0.17 h / 0 °C

5: 81 percent / chlorobenzene / 2.5 h / 130 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chlorobenzene;
DOI:10.1021/ja00368a058