2',3'-Dideoxy-4-thiouridine

Base Information

Chemical Name:2',3'-Dideoxy-4-thiouridine
CAS No.:122568-04-1
Molecular Formula:C₉H₁₂N₂O₃S
Molecular Weight:228.272
Hs Code.:
DSSTox Substance ID:DTXSID50153651
Nikkaji Number:J264.463K
ChEMBL ID:CHEMBL89055
Mol file:122568-04-1.mol

Synonyms:2',3'-dideoxy-4-thiouridine;ddUrdS;4-Thio-ddU;122568-04-1;CHEMBL89055;SCHEMBL5317524;DTXSID50153651;HFUKRBLAIFTSMI-POYBYMJQSA-N;2/',3/'-Dideoxy-4-thiouridine;BDBM50013119;1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one;1-(5-Hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one (ddUrdS)

Suppliers and Price of 2',3'-Dideoxy-4-thiouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2',3'-Dideoxy-4-thiouridine

Chemical Property:

PSA：103.15000
Density:1.47g/cm³
LogP:0.20190
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:228.05686342
Heavy Atom Count:15
Complexity:319

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(OC1CO)N2C=CC(=S)NC2=O
Isomeric SMILES:C1C[C@@H](O[C@@H]1CO)N2C=CC(=S)NC2=O

Technology Process of 2',3'-Dideoxy-4-thiouridine

There total 5 articles about 2',3'-Dideoxy-4-thiouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 122568-04-1
2',3'-dideoxy-4-thio-uridine

Guidance literature:

Reference yield: 70.0%

: 122568-01-8
5'-O-benzoyl-2',3'-dideoxy-4-thiouridine

: 122568-04-1
2',3'-dideoxy-4-thio-uridine

Guidance literature:: With sodium hydroxide; for 6h; Ambient temperature;
DOI:10.1021/jm00163a043

Reference yield:

: 6038-56-8
1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl)uracil

: 122568-04-1
2',3'-dideoxy-4-thio-uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 1292.9 Torr

2: 75 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide / toluene / 12 h / 80 °C

3: 70 percent / 1 N aq. NaOH / 6 h / Ambient temperature

With Lawessons reagent; sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00163a043