2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole

Base Information

• Chemical Name: 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole
• CAS No.: 332941-40-9
• Molecular Formula: C₂₁H₂₁N₄P
• Molecular Weight: 360.398
• Mol file: 332941-40-9.mol

Synonyms:2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole

Chemical Property of 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole

There total 2 articles about 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

bis(N-methylimidazol-2-yl)methane (124225-99-6) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole (332941-40-9)

Guidance literature:

bis(N-methylimidazol-2-yl)methane; With n-butyllithium; In tetrahydrofuran; hexane; at -80 - -45 ℃; for 1.5h;

chloro-diphenylphosphine; In tetrahydrofuran; hexane; at -80 - -30 ℃;

DOI:10.1055/s-2001-12351

Reference yield:

bis(N-methylimidazol-2-yl)ketone (62366-40-9) → 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole (332941-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 83 percent / KOH; hydrazine hydrate / 4 h / 120 - 150 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -80 - -45 °C

2.2: 85 percent / tetrahydrofuran; hexane / -80 - -30 °C

With potassium hydroxide; n-butyllithium; hydrazine hydrate; In tetrahydrofuran; hexane;

DOI:10.1055/s-2001-12351

Reference yield: 90.0%

trichlorotris(tetrahydrofuran)chromium(III) (10170-68-0,16997-54-9) + 2-[(Diphenylphosphino)(1-methyl-1H-imidazol-2-yl)methyl]-1-methyl-1H-imidazole (332941-40-9) → [Cr((2-(diphenylphosphino)(N-methylimidazol-2-yl)methyl)-N-methylimidazole)Cl3]2 (332941-53-4)

Guidance literature:

In dichloromethane; a soln. of ligand in CH2Cl2 was added to a soln. of complex in CH2Cl2, the mixt. was stirred for 12 h (N2); the solvent was sepd., the product was stirred in CH2Cl2 overnight, CH2Cl2 was removed, ppt. was washed with CH2Cl2 and hexane, dried in vac.; elem. anal.;

DOI:10.1021/om000846b

upstream raw materials:

bis(N-methylimidazol-2-yl)methane

chloro-diphenylphosphine

bis(N-methylimidazol-2-yl)ketone

Downstream raw materials:

[Cr((2-(diphenylphosphino)(N-methylimidazol-2-yl)methyl)-N-methylimidazole)Cl₃]2