C₂₄H₁₆FN₃

Base Information

Chemical Name:C₂₄H₁₆FN₃
CAS No.:1450729-49-3
Molecular Formula:C₂₄H₁₆FN₃
Molecular Weight:365.41
Hs Code.:

C<sub>24</sub>H<sub>16</sub>FN<sub>3</sub>

Synonyms:C₂₄H₁₆FN₃

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Chemical Property of C₂₄H₁₆FN₃

Chemical Property:

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Technology Process of C₂₄H₁₆FN₃

There total 5 articles about C₂₄H₁₆FN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1450729-39-1
C₁₉H₁₅N₃S

: 460-00-4
1-Bromo-4-fluorobenzene

: 1450729-49-3
C₂₄H₁₆FN₃

Guidance literature:: With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); magnesium; ethylene dibromide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0033-1338951

Reference yield:

: 1450729-32-4
7-(tert-butoxycarbonyl)-4-chloro-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine

: 1450729-49-3
C₂₄H₁₆FN₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: CyJohnPhos; palladium diacetate / 1,4-dioxane / 0.17 h / Inert atmosphere

1.2: 1 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3.1: potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 13 h / Inert atmosphere; Reflux

4.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); magnesium; ethylene dibromide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); trans-1,2-Diaminocyclohexane; palladium diacetate; magnesium; ethylene dibromide; trifluoroacetic acid; CyJohnPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling / 4.1: |Kumada Cross-Coupling;
DOI:10.1055/s-0033-1338951

Reference yield:

: 1450729-33-5
C₁₈H₁₉N₃O₂S

: 1450729-49-3
C₂₄H₁₆FN₃

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 13 h / Inert atmosphere; Reflux

3: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); magnesium; ethylene dibromide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); trans-1,2-Diaminocyclohexane; magnesium; ethylene dibromide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 3: |Kumada Cross-Coupling;
DOI:10.1055/s-0033-1338951