Technology Process of (2R,3R)-2-benzylamino-3-cyclohexyl-3-hydroxypropanoic acid
There total 9 articles about (2R,3R)-2-benzylamino-3-cyclohexyl-3-hydroxypropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[(2S,3R)-3-cyclohexyloxiran-2-yl]carboxylic acid; benzylamine;
With
sodium hydroxide;
In
water;
for 2.5h;
Reflux;
With
sodium hydroxide;
In
water;
at 20 ℃;
With
hydrogenchloride;
In
water;
pH=4 - 5;
regioselective reaction;
DOI:10.1016/j.bmc.2011.05.022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; Cumene hydroperoxide / dichloromethane / Molecular sieve
2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide
3: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile
4: sodium hydroxide / water
With
titanium(IV) isopropylate; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diethyl (2S,3S)-tartrate; Cumene hydroperoxide; sulfur trioxide pyridine complex; triethylamine; sodium hydroxide;
In
dichloromethane; water; dimethyl sulfoxide; acetonitrile;
1: Sharpless epoxidation;
DOI:10.1016/j.bmcl.2010.12.109
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sulfuric acid / methanol
2: diisobutylaluminium hydride / tetrahydrofuran
3: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; Cumene hydroperoxide / dichloromethane / Molecular sieve
4: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide
5: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile
6: sodium hydroxide / water
With
titanium(IV) isopropylate; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diethyl (2S,3S)-tartrate; Cumene hydroperoxide; sulfuric acid; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
3: Sharpless epoxidation;
DOI:10.1016/j.bmcl.2010.12.109
![[(2S,3R)-3-cyclohexyloxiran-2-yl]carboxylic acid](/Databaselist/images/loading.webp)
