ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate
CAS No.:119474-34-9
Molecular Formula:C₂₀H₁₆F₃NO₄S
Molecular Weight:423.413
Hs Code.:

Synonyms:ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

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Chemical Property of ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

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Technology Process of ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

There total 4 articles about ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 119474-33-8
diethyl <(2,3,4-trifluoroanilino)<(4-methoxybenzyl)thio>methylene>malonate

: 119474-34-9
ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

Guidance literature:: In diphenylether; at 250 - 260 ℃; for 0.0833333h;
DOI:10.1021/jm00070a005

Reference yield:

: 119474-39-4
triethylammonium N-(2,3,4-trifluorophenyl)dithiocarbamate

: 119474-34-9
ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / triethylamine, ethyl chloroformate / CHCl₃ / 0.17 h / 2 - 6 °C

2: 1.) sodium hydride / 1.) THF, 5-10 deg C, 10 min, 2.) THF, RT, 105 min

3: 95 percent / dimethylformamide / 1 h / Ambient temperature

4: 82 percent / diphenyl ether / 0.08 h / 250 - 260 °C

With chloroformic acid ethyl ester; sodium hydride; triethylamine; In diphenylether; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a005

Reference yield:

: 119474-40-7
2,3,4-trifluorophenyl isothiocyanate

: 119474-34-9
ethyl 4-hydroxy-2-<(4-methoxybenzyl)thio>-6,7,8-trifluoroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) THF, 5-10 deg C, 10 min, 2.) THF, RT, 105 min

2: 95 percent / dimethylformamide / 1 h / Ambient temperature

3: 82 percent / diphenyl ether / 0.08 h / 250 - 260 °C

With sodium hydride; In diphenylether; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a005