Technology Process of (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid
There total 10 articles about (3S)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)-3-(3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-5-(trifluoromethyl)phenyl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate;
In
water; acetonitrile;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
2.2: 3 h / 20 °C
3.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
4.1: ammonium acetate / ethanol / 7 h / 80 °C
5.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction
5.2: 0.25 h / 20 °C
6.1: hydrogenchloride / 3 h / Reflux; Inert atmosphere
7.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere
7.2: 20 °C / Inert atmosphere
8.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C
With
hydrogenchloride; potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; sodium hydroxide;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; di-isopropyl ether; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: ammonium acetate / ethanol / 7 h / 80 °C
3.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 144 h / 20 °C / pH 8.25 / Enzymatic reaction
3.2: 0.25 h / 20 °C
4.1: hydrogenchloride / 3 h / Reflux; Inert atmosphere
5.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
6.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C
With
hydrogenchloride; potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; lithium hydroxide monohydrate; ammonium acetate; benzotriazol-1-ol; sodium hydroxide;
In
ethanol; hexane; dichloromethane; di-isopropyl ether; water; N,N-dimethyl-formamide; acetonitrile;
