11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one

Base Information

• Chemical Name: 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one
• CAS No.: 958008-44-1
• Molecular Formula: C₂₅H₂₁NO₃
• Molecular Weight: 383.447
• Mol file: 958008-44-1.mol

Synonyms:11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one

Chemical Property of 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one

There total 5 articles about 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-(4-methoxybenzyl)-2-methyl-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione → 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one (958008-44-1)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride heptahydrate; In methanol; dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1002/chem.201501152

Reference yield: 78.0%

C25H21NO3 → 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one (958008-44-1)

Guidance literature:

With hydrogenchloride; In acetone;

DOI:10.1016/j.bmcl.2007.08.062

Reference yield:

6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one → 11-hydroxy-6-(4-methoxybenzyl)-2-methyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one (958008-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide / 1,4-dioxane / 48 h / 100 °C

2: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol; dichloromethane / 0.25 h / 0 °C

With selenium(IV) oxide; sodium tetrahydroborate; cerium(III) chloride heptahydrate; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1002/chem.201501152