(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
CAS No.:238428-10-9
Molecular Formula:C₁₉H₁₇FN₂O₂
Molecular Weight:324.355
Hs Code.:

Synonyms:(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Chemical Property of (1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Technology Process of (1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

There total 3 articles about (1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 459-57-4
4-fluorobenzaldehyde

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 238428-10-9
(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With sodium carbonate; In methanol;
DOI:10.1016/S0968-0896(99)00050-4

Reference yield: 35.0%

: 459-57-4
4-fluorobenzaldehyde

: 4299-70-1
L-tryptophan methyl ester

: (1R,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 238428-10-9
(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In methanol; at 110 ℃; for 0.75h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.0c00816

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: (1R,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 238428-10-9
(1S,3S)-methyl 1-(4-fluorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 0 - 20 °C

2: toluene-4-sulfonic acid / toluene / 12 h / Reflux

With thionyl chloride; toluene-4-sulfonic acid; In toluene; 2: |Pictet-Spengler Synthesis;
DOI:10.1016/j.bioorg.2015.02.007