C₅₁H₇₄ClIN₂O₁₂Si₂

Base Information

Chemical Name:C₅₁H₇₄ClIN₂O₁₂Si₂
CAS No.:253189-23-0
Molecular Formula:C₅₁H₇₄ClIN₂O₁₂Si₂
Molecular Weight:1125.68
Hs Code.:

C<sub>51</sub>H<sub>74</sub>ClIN<sub>2</sub>O<sub>12</sub>Si<sub>2</sub>

Synonyms:C₅₁H₇₄ClIN₂O₁₂Si₂

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Chemical Property of C₅₁H₇₄ClIN₂O₁₂Si₂

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Technology Process of C₅₁H₇₄ClIN₂O₁₂Si₂

There total 17 articles about C₅₁H₇₄ClIN₂O₁₂Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (2R,3R)-3-Ethynyl-2-(4-methoxy-benzyloxymethoxy)-6-triethylsilanyl-hex-5-yne-1,3-diol

: 253189-21-8
(R)-3-tert-Butoxycarbonylamino-3-{5-[(5R,6R,7S)-6-(tert-butyl-dimethyl-silanyloxy)-9-iodo-2,2-dimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-yloxy]-6-chloro-pyridin-2-yl}-propionic acid

: 253189-23-0
C₅₁H₇₄ClIN₂O₁₂Si₂

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0040-4039(99)01744-X

Reference yield:

: 253189-15-0
(3S,6S,7R)-4-Iodo-6,7-bis-methoxymethoxy-1-oxa-spiro[2.4]hept-4-ene

: 253189-23-0
C₅₁H₇₄ClIN₂O₁₂Si₂

Guidance literature:: Multi-step reaction with 16 steps

1: 61 percent / HClO₄ / tetrahydrofuran; H₂O

2: 91 percent / Et₃N; DMAP / CH₂Cl₂

3: 74 percent / PPTS / butan-2-one / Heating

4: 96 percent / imidazole / dimethylformamide

5: 97 percent / PPTS / CH₂Cl₂

6: 85 percent / TBAF / tetrahydrofuran / -40 °C

7: 98 percent / K₂CO₃ / methanol

8: DIAD; PPh₃ / toluene

9: pyridine

10: CsF / dimethylformamide / 60 °C

11: imidazole / dimethylformamide / 50 °C

12: 91 percent / K₂CO₃ / methanol

13: 93 percent / PPTS / methanol

14: 90 percent / PPTS / dimethylformamide

15: 96 percent / H₂O; KOH / tetrahydrofuran; methanol

16: 75 percent / EDC*HCl; DMAP / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; potassium hydroxide; perchloric acid; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; cesium fluoride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; butanone; 1: Ring cleavage / 2: Acetylation / 3: ether cleavage; rearrangement / 4: silylation / 5: Addition / 6: desilylation / 7: Deacetylation / 8: Cyclization / 9: Acetylation / 10: Addition / 11: silylation / 12: Deacetylation / 13: ether cleavage / 14: Substitution / 15: Hydrolysis / 16: Esterification;
DOI:10.1016/S0040-4039(99)01744-X

Reference yield:

: [(1R,2R,5R)-2-(2-Ethoxy-ethoxy)-3-iodo-6-oxa-bicyclo[3.1.0]hex-3-en-2-yl]-methanol

: 253189-23-0
C₅₁H₇₄ClIN₂O₁₂Si₂

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine

2: CsF / dimethylformamide / 60 °C

3: imidazole / dimethylformamide / 50 °C

4: 91 percent / K₂CO₃ / methanol

5: 93 percent / PPTS / methanol

6: 90 percent / PPTS / dimethylformamide

7: 96 percent / H₂O; KOH / tetrahydrofuran; methanol

8: 75 percent / EDC*HCl; DMAP / CH₂Cl₂

With pyridine; 1H-imidazole; dmap; potassium hydroxide; water; pyridinium p-toluenesulfonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Addition / 3: silylation / 4: Deacetylation / 5: ether cleavage / 6: Substitution / 7: Hydrolysis / 8: Esterification;
DOI:10.1016/S0040-4039(99)01744-X