4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Base Information

Chemical Name:4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate
CAS No.:1351646-23-5
Molecular Formula:C₂₄H₂₄FNO₅
Molecular Weight:425.457
Hs Code.:

Synonyms:4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

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Chemical Property of 4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

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Technology Process of 4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

There total 4 articles about 4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3-acetyl-1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indole

: 95-92-1
oxalic acid diethyl ester

: 1351646-23-5
4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: With sodium methylate; In tetrahydrofuran; at 50 ℃; for 0.0333333h; Microwave irradiation;
DOI:10.3390/molecules16086858

Reference yield:

: 73260-12-5
3-acetyl-4-methoxy-1H-indole

: 1351646-23-5
4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C

1.2: 0.08 h / 50 °C / Microwave irradiation

2.1: sodium methylate / tetrahydrofuran / 0.03 h / 50 °C / Microwave irradiation

With sodium methylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3390/molecules16086858

Reference yield:

: 4837-90-5
4-methoxy-1H-indole

: 1351646-23-5
4-[1-(4-fluoro-3,5-dimethylbenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C

2.2: 0.08 h / 50 °C / Microwave irradiation

3.1: sodium methylate / tetrahydrofuran / 0.03 h / 50 °C / Microwave irradiation

With sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Vilsmeier-Haack reaction;
DOI:10.3390/molecules16086858