4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester
CAS No.:887973-32-2
Molecular Formula:C₂₄H₃₀F₃N₃O₇
Molecular Weight:529.513
Hs Code.:

4-<i>tert</i>-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3<i>H</i>-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Synonyms:4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

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Chemical Property of 4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

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Technology Process of 4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

There total 10 articles about 4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 885477-47-4
7-tert-butoxycarbonylmethyl-6-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

: 887973-32-2
4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2005-923595

Reference yield:

: C₁₆H₁₄F₃NO₅S

: 887973-32-2
4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NH₃

2: 73 percent / I₂; Et₃N / methanol

3: 62 percent / TiCl₄ / CH₂Cl₂

4: 91 percent / NaBH₄

5: 90 percent / PPh₃; CBr₄ / diethyl ether

6: 23 percent / NaH

7: 74 percent / CF₃CO₂H / CH₂Cl₂

With sodium tetrahydroborate; carbon tetrabromide; ammonia; iodine; titanium tetrachloride; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; 3: Friedel-Crafts alkylation;
DOI:10.1055/s-2005-923595

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 887973-32-2
4-tert-butoxycarbonylmethyl-5-hydroxymethyl-3-[2-methoxy-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzyl]-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 77 percent / n-BuLi

2: 92 percent / NH₂OH*HCl; C₅H₅N

3: 93 percent / C₅H₅N

4: 88 percent / NH₃

5: 73 percent / I₂; Et₃N / methanol

6: 62 percent / TiCl₄ / CH₂Cl₂

7: 91 percent / NaBH₄

8: 90 percent / PPh₃; CBr₄ / diethyl ether

9: 23 percent / NaH

10: 74 percent / CF₃CO₂H / CH₂Cl₂

With pyridine; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; hydroxylamine hydrochloride; ammonia; iodine; titanium tetrachloride; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; 6: Friedel-Crafts alkylation;
DOI:10.1055/s-2005-923595