4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile

Base Information

• Chemical Name: 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile
• CAS No.: 3648-76-8
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.268
• Mol file: 3648-76-8.mol

Synonyms:4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile

Chemical Property of 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile

There total 2 articles about 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

3-oxa-1,5-dichloropentane (111-44-4) + 2-tolylmethylnitrile (22364-68-7) → 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile (3648-76-8)

Guidance literature:

With sodium hydride; In toluene; for 4h;

DOI:10.1007/BF02256974

Reference yield:

3-oxa-1,5-dichloropentane (111-44-4) + 2-tolylmethylnitrile (22364-68-7) → 4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile (3648-76-8) + 4-(2-chloro-ethoxy)-2-o-tolyl-butyronitrile

Guidance literature:

With dibenzo-18-crown-6; Title compound not separated from byproducts; Heating;

DOI:10.1007/BF02256974

Reference yield: 91.0%

4-(2-methylphenyl)tetrahydro-2H-4-pyrancarbonitrile (3648-76-8) → 4-(2-bromomethylphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carbonitrile (333429-10-0)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 14h; Heating;

DOI:10.1007/BF02256974

upstream raw materials:

3-oxa-1,5-dichloropentane

2-tolylmethylnitrile

Downstream raw materials:

4-(2-bromomethylphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carbonitrile

4-[2-(benzylaminomethyl)phenyl]tetrahydro-2H-pyran-4-carbonitrile