(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

Base Information

Chemical Name:(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid
CAS No.:1402041-74-0
Molecular Formula:C₂₅H₁₇ClN₂O₂
Molecular Weight:412.875
Hs Code.:

Synonyms:(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

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Chemical Property of (3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

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Technology Process of (3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

There total 10 articles about (3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1402041-83-1
ethyl 2-(3-(4-(2-(3-chlorophenyl)ethynyl)phenyl)-1-phenyl-1H-pyrazol-4-yl)acetate

: 1402041-74-0
(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

Guidance literature:: ethyl 2-(3-(4-(2-(3-chlorophenyl)ethynyl)phenyl)-1-phenyl-1H-pyrazol-4-yl)acetate; With sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 5h;

With hydrogenchloride; In water; pH=1;
DOI:10.1021/jm3010543

Reference yield:

: 1402041-80-8
ethyl [3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl]acetate

: 1402041-74-0
(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane / Inert atmosphere

2.1: sodium hydroxide / ethanol; dimethyl sulfoxide / 5 h / 20 °C

2.2: pH 1

With palladium diacetate; caesium carbonate; sodium hydroxide; XPhos; In 1,4-dioxane; ethanol; dimethyl sulfoxide; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm3010543

Reference yield:

: 36640-41-2
3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1402041-74-0
(3-{4-[(3-chlorophenyl)ethynyl]phenyl}-1-phenyl-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux

2.1: thionyl chloride / toluene / 3 h / 45 - 70 °C

3.1: dimethyl sulfoxide / 1.5 h / 20 - 45 °C

4.1: sulfuric acid; water / 2.5 h / 125 °C

5.1: sulfuric acid / 2 h / 60 °C

6.1: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane / Inert atmosphere

7.1: sodium hydroxide / ethanol; dimethyl sulfoxide / 5 h / 20 °C

7.2: pH 1

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; water; palladium diacetate; caesium carbonate; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; toluene; 6.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm3010543