5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

Base Information

Chemical Name:5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine
CAS No.:1401327-38-5
Molecular Formula:C₃₆H₃₈N₄O₉
Molecular Weight:670.719
Hs Code.:

Synonyms:5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

Suppliers and Price of 5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

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Technology Process of 5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

There total 7 articles about 5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1401327-14-7
2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1401327-38-5
5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

Guidance literature:: With pyridine; at 25 ℃; for 2.5h;
DOI:10.1002/chem.201204235

Reference yield:

: 19295-57-9
3-hydroxy-2,2-dimethylpropionitrile

: 1401327-38-5
5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C

1.2: -78 - 25 °C

2.1: methanol; water; hydrogenchloride / 1 h / 55 °C

3.1: pyridine / 2.5 h / 25 °C

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201204235

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 1401327-38-5
5’-O-(4,4’-dimethoxytrityl)-2’-O-(2-cyano-2,2-dimethylethanimine-N-oxymethyl)uridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; water; hydroxylamine hydrochloride / ethanol / 48 h / 70 °C / Cooling with ice

2.1: trifluoroacetic anhydride / -15 °C / Reflux

3.1: methanol / 16 h / 25 °C

4.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C

4.2: -78 - 25 °C

5.1: methanol; water; hydrogenchloride / 1 h / 55 °C

6.1: pyridine / 2.5 h / 25 °C

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; hydroxylamine hydrochloride; water; potassium carbonate; trifluoroacetic anhydride; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201204235