3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

Base Information

Chemical Name:3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione
CAS No.:1026855-63-9
Molecular Formula:C₂₀H₂₂ClN₃O₄S
Molecular Weight:435.931
Hs Code.:

Synonyms:3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

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Chemical Property of 3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

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Technology Process of 3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

There total 3 articles about 3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-{3-[4-(4-Chloro-phenoxy)-phenylsulfanyl]-2-[(Z)-hydroxyimino]-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

: 1026855-63-9
3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; borane pyridine; In tetrahydrofuran; 1,4-dioxane; ethanol; at 20 ℃; for 5h;
DOI:10.1021/jm0103920

Reference yield:

: 1836-74-4
4-(4-chlorophenoxy)nitrobenzene

: 1026855-63-9
3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NH₄Cl; Fe / methanol

2.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

2.2: aq. HCl / 1 h / 70 °C

3.1: KOH / ethanol / 2 h / 80 °C

4.1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

5.1: HONH₂*HCl; pyridine / ethanol; tetrahydrofuran / 16 h / 23 °C

6.1: BH₃*pyr; HCl / ethanol; tetrahydrofuran; dioxane / 5 h / 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; borane pyridine; hydroxylamine hydrochloride; iron; potassium carbonate; ammonium chloride; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920

Reference yield:

: 101-79-1
4-amino-4'-chlorodiphenyl ether

: 1026855-63-9
3-{3-[4-(4-chloro-phenoxy)-phenylsulfanyl]-2-hydroxyamino-propyl}-5,5-dimethyl-imidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

1.2: aq. HCl / 1 h / 70 °C

2.1: KOH / ethanol / 2 h / 80 °C

3.1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

4.1: HONH₂*HCl; pyridine / ethanol; tetrahydrofuran / 16 h / 23 °C

5.1: BH₃*pyr; HCl / ethanol; tetrahydrofuran; dioxane / 5 h / 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; borane pyridine; hydroxylamine hydrochloride; potassium carbonate; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0103920