methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

Base Information

Chemical Name:methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate
CAS No.:223467-41-2
Molecular Formula:C₂₃H₂₅NO₆
Molecular Weight:411.455
Hs Code.:

Synonyms:methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

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Chemical Property of methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

Chemical Property:

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Technology Process of methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

There total 7 articles about methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 223467-37-6
methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-hydroxypentanoate

: 107-30-2
chloromethyl methyl ether

: 223467-41-2
methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 223467-41-2
methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 88 percent / SOCl₂ / 3 h / Heating

4: 81 percent / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

5: borane tetrahydrofuran complex / tetrahydrofuran / 4 h / 20 °C

6: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; thionyl chloride; borane-THF; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 223467-41-2
methyl (4S)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-5-(methoxymethoxy)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 88 percent / SOCl₂ / 3 h / Heating

4: 81 percent / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

5: borane tetrahydrofuran complex / tetrahydrofuran / 4 h / 20 °C

6: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; thionyl chloride; borane-THF; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032