(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
CAS No.:138353-60-3
Molecular Formula:C₂₂H₂₀F₃NO₆
Molecular Weight:451.399
Hs Code.:

Synonyms:(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Chemical Property of (3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Technology Process of (3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

There total 7 articles about (3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 138353-59-0
(3R,4S-cis)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-1-(2-hydroxyethyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 138353-60-3
(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide; for 25h; Ambient temperature;
DOI:10.1021/jm00082a018

Reference yield:

: 138384-10-8
(3R,4S)-3-Hydroxy-4-(4-methoxy-phenyl)-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 138353-60-3
(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / DMAP / CH₂Cl₂ / 29 h / Ambient temperature

2: 45 percent / 1 N HCl / tetrahydrofuran / 24 h / Ambient temperature

3: 30 percent / pyridinium dichromate / dimethylformamide / 25 h / Ambient temperature

With hydrogenchloride; dmap; dipyridinium dichromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a018

Reference yield:

: 138840-02-5
Acetic acid (3R,4S)-4-(4-methoxy-phenyl)-2-oxo-1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

: 138353-60-3
(3R,4S-cis)-1-(carboxymethyl)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-acetoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1 N HCl / tetrahydrofuran / 24 h / Ambient temperature

2: 30 percent / pyridinium dichromate / dimethylformamide / 25 h / Ambient temperature

With hydrogenchloride; dipyridinium dichromate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a018