2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

Base Information

Chemical Name:2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone
CAS No.:105857-82-7
Molecular Formula:C₄₄H₅₈O₆
Molecular Weight:682.941
Hs Code.:

2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

Synonyms:2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

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Chemical Property of 2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

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Technology Process of 2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

There total 6 articles about 2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13735-81-4
1-styrenyloxytrimethylsilane

: 105857-82-7
2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / TiCl₄ / CH₂Cl₂ / -85 °C

2: 1) nBu₄NF / 1) THF, 30 min, RT, 2) THF, 2 h

3: p-TsOH / CH₂Cl₂ / 16 h / Ambient temperature

With tetrabutyl ammonium fluoride; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/ja00236a034

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 105857-82-7
2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

2: 67 percent / TiCl₄ / CH₂Cl₂ / -85 °C

3: 1) nBu₄NF / 1) THF, 30 min, RT, 2) THF, 2 h

4: p-TsOH / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/ja00236a034

Reference yield:

: 105857-78-1
5,7,8-Trimethyl-6-trimethylsilanyloxy-2,2-bis-trimethylsilanyloxymethyl-chroman

: 105857-82-7
2-{(1R,2S,5R)-1-[(R)-6-Benzyloxy-5,7,8-trimethyl-2-(tetrahydro-pyran-2-yloxymethyl)-chroman-2-ylmethoxy]-2-isopropyl-5-methyl-cyclohexyl}-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1) TMSOTf, 2) pyridine, 0.5percent NaOH in MeOH / 1) -85 deg C, 2) RT, 1 h

2: 67 percent / TiCl₄ / CH₂Cl₂ / -85 °C

3: 1) nBu₄NF / 1) THF, 30 min, RT, 2) THF, 2 h

4: p-TsOH / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; titanium tetrachloride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/ja00236a034