3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

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Chemical Name:3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione
CAS No.:847685-04-5
Molecular Formula:C₂₃H₁₉BrF₂N₂O₂
Molecular Weight:473.317
Hs Code.:

3-bromo-1-(4-<i>tert</i>-butyl-benzyl)-4-(5,6-difluoro-1<i>H</i>-indol-3-yl)-pyrrole-2,5-dione

Synonyms:3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

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Chemical Property of 3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

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Technology Process of 3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

There total 5 articles about 3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 169674-01-5
5,6-difluoro-1H-indole

: 204194-28-5
N-(4-t-butylbenzyl)-3,4-dibromomaleimide

: 847685-04-5
3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: 5,6-difluoro-1H-indole; With ethylmagnesium bromide;

N-(4-t-butylbenzyl)-3,4-dibromomaleimide; at 20 - 50 ℃; for 5h;
DOI:10.1016/j.tetlet.2004.12.068

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 847685-04-5
3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / ICl / acetic acid / 0.5 h / 20 °C

2.1: 89 percent / pyridine / 2 h / 0 °C

3.1: 94 percent / (o-tolyl)3P / Pd(OAc)2 / triethylamine / 16 h / 20 °C

4.1: 82 percent / EtONa / ethanol / 14 h / 70 °C

5.1: EtMgBr

5.2: 91 percent / 5 h / 20 - 50 °C

With ethylmagnesium bromide; sodium ethanolate; Iodine monochloride; tris-(o-tolyl)phosphine; palladium diacetate; In pyridine; ethanol; acetic acid; triethylamine; 3.1: Heck coupling;
DOI:10.1016/j.tetlet.2004.12.068

Reference yield:

: 847685-01-2
2-iodo-4,5-difluoroaniline

: 847685-04-5
3-bromo-1-(4-tert-butyl-benzyl)-4-(5,6-difluoro-1H-indol-3-yl)-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / pyridine / 2 h / 0 °C

2.1: 94 percent / (o-tolyl)3P / Pd(OAc)2 / triethylamine / 16 h / 20 °C

3.1: 82 percent / EtONa / ethanol / 14 h / 70 °C

4.1: EtMgBr

4.2: 91 percent / 5 h / 20 - 50 °C

With ethylmagnesium bromide; sodium ethanolate; tris-(o-tolyl)phosphine; palladium diacetate; In pyridine; ethanol; triethylamine; 2.1: Heck coupling;
DOI:10.1016/j.tetlet.2004.12.068