(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

Base Information

Chemical Name:(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate
CAS No.:1352317-65-7
Molecular Formula:C₁₇H₁₆F₃NO₄S
Molecular Weight:387.38
Hs Code.:

Synonyms:(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

Suppliers and Price of (1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

There total 1 articles about (1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 1352317-65-7
(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / diethyl ether; hexane / 2 h / -20 °C / Inert atmosphere

1.2: 1 h / -20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 80 °C / Inert atmosphere

3.1: water; bis-[(trifluoroacetoxy)iodo]benzene / tetrahydrofuran; methanol; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

With water; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; toluene; 2.1: Buchwald-Hartwig cyclization;
DOI:10.1016/j.tet.2011.10.028

Reference yield: 92.0%

: 1352317-65-7
(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

: 98-80-6
phenylboronic acid

: 1352317-69-1
(1'R,7a'S)-7a'-methyl-5'-phenyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-indene]

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; toluene; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.10.028

Reference yield: 56.0%

: 1352317-65-7
(1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl trifluoromethanesulfonate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1352317-72-6
4-((1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl)phenol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; toluene; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2011.10.028