3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

Base Information

Chemical Name:3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide
CAS No.:1428639-44-4
Molecular Formula:C₃₆H₃₂FN₃O₅
Molecular Weight:605.666
Hs Code.:

Synonyms:3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

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Chemical Property of 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

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Technology Process of 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

There total 15 articles about 3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428640-14-5
3-(2-fluorophenyl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxylic acid

: 154-09-6,526-53-4,2899-29-8,52485-52-6
(2R)-2-amino-3-(1H-indol-3-yl)propan-1-ol

: 1428639-44-4
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428639-44-4
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: iron; acetic acid / 2 h / 85 °C

2.1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere

5.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C

8.1: water; sodium hydroxide / methanol / 2 h / 60 °C

9.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; HATU; sodium hydroxide; sodium nitrite; tricyclohexylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1428639-87-5
methyl 5-amino-2'-fluorobiphenyl-2-carboxylate

: 1428639-44-4
3-(2-fluorophenyl)-N-((R)-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-(morpholine-4-carbonyl)-6H-benzo[c]chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C

7.1: water; sodium hydroxide / methanol / 2 h / 60 °C

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; sodium hydride; potassium carbonate; triethylamine; HATU; sodium hydroxide; sodium nitrite; tricyclohexylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: |Sonogashira Cross-Coupling;