(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Base Information

Chemical Name:(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide
CAS No.:1398717-83-3
Molecular Formula:C₂₇H₃₅N₅O₃S
Molecular Weight:509.673
Hs Code.:

Synonyms:(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Chemical Property of (S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Technology Process of (S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

There total 9 articles about (S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1398718-42-7
(S)-(9H-fluoren-9-yl)methyl 1-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)-biphenyl-4-yl)ethylcarbamoyl)cyclohexylcarbamate

: 1398717-83-3
(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 1398717-83-3
(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / Reflux

2: sodium hydrogencarbonate / acetone / 20 °C

3: ammonia; methanol / 0.25 h / -50 - 20 °C

4: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

5: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

6: formic acid / 4 h / 20 °C

7: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0 - 20 °C

8: piperidine / dichloromethane / 2 h / 20 °C

With piperidine; methanol; formic acid; thionyl chloride; 1,3,5-trichloro-2,4,6-triazine; ammonia; sodium hydrogencarbonate; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 62129-39-9,79561-82-3
4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

: 1398717-83-3
(S)-1-amino-N-(1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: ammonia; methanol / 0.25 h / -50 - 20 °C

3: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

4: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5: formic acid / 4 h / 20 °C

6: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0 - 20 °C

7: piperidine / dichloromethane / 2 h / 20 °C

With piperidine; methanol; formic acid; 1,3,5-trichloro-2,4,6-triazine; ammonia; sodium carbonate; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dichloromethane; water; N,N-dimethyl-formamide;