1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline
CAS No.:754977-12-3
Molecular Formula:C₂₄H₃₈N₂O
Molecular Weight:370.579
Hs Code.:
DSSTox Substance ID:DTXSID901138843
Pharos Ligand ID:FJPVX9HU9TA7
ChEMBL ID:CHEMBL210252

Synonyms:CHEMBL210252;SCHEMBL6109905;DTXSID901138843;BDBM50186268;1-(Cyclohexylmethyl)-1,2,3,4-tetrahydro-6-[3-(1-piperidinyl)propoxy]quinoline;1-(cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline;754977-12-3

Suppliers and Price of 1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:370.298413840
Heavy Atom Count:27
Complexity:417

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(CC1)CN2CCCC3=C2C=CC(=C3)OCCCN4CCCCC4

Technology Process of 1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline

There total 7 articles about 1-(Cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5263-87-6
6-methoxy quinoline

: 754977-12-3
1-cyclohexylmethyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / PtO₂ / methanol / 12 h / 3102.89 Torr

2: BBr₃ / CH₂Cl₂ / 4 h / -78 °C

3: NaOH / dioxane

4: Cs₂CO₃; KI / dimethylformamide / 90 °C

5: HCl / dioxane; CH₂Cl₂ / 20 °C

6: MP-CNBH₃ / CH₂Cl₂; methanol / 20 °C

With hydrogenchloride; sodium hydroxide; MP-CNBH₃; hydrogen; boron tribromide; caesium carbonate; potassium iodide; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.004

Reference yield:

: 6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline dihydrochloride

: 2043-61-0
cyclohexanecarbaldehyde

: 754977-12-3
1-cyclohexylmethyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With MP-CNBH₃; In methanol; dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.04.004

Reference yield:

: 327044-56-4
6-Hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester

: 754977-12-3
1-cyclohexylmethyl-6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃; KI / dimethylformamide / 90 °C

2: HCl / dioxane; CH₂Cl₂ / 20 °C

3: MP-CNBH₃ / CH₂Cl₂; methanol / 20 °C

With hydrogenchloride; MP-CNBH₃; caesium carbonate; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.004