N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide
CAS No.:1236060-10-8
Molecular Formula:C₂₅H₃₀N₂O₃
Molecular Weight:406.525
Hs Code.:

Synonyms:N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

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Chemical Property of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Chemical Property:

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Technology Process of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

There total 8 articles about N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂N₂O₅

: 1236060-10-8
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.10.071

Reference yield:

: 79607-24-2,85418-82-2
6-methyl-4-carbonylquinoline-3-carboxylic acid ethyl ester

: 1236060-10-8
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water / 3 h / 100 °C

1.2: pH 4 - 5

2.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

3.1: potassium hydroxide / methanol / 2 h / 20 °C

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.10.071

Reference yield:

: 96-76-4
2,4-di-tert-Butylphenol

: 1236060-10-8
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: nitric acid; sulfuric acid / 2 h / 0 - 20 °C

3: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux

4: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

5: potassium hydroxide / methanol / 2 h / 20 °C

With dmap; sulfuric acid; palladium 10% on activated carbon; nitric acid; ammonium formate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.10.071