2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

Base Information

Chemical Name:2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one
CAS No.:1246249-63-7
Molecular Formula:C₂₀H₁₉F₃N₄O
Molecular Weight:388.392
Hs Code.:

Synonyms:2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

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Chemical Property of 2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

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Technology Process of 2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

There total 4 articles about 2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1246249-65-9
2-[4-(piperazin-1-yl)phenyl]quinazolin-4(3H)-one

: 1246249-63-7
2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 15h; Reflux;

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 1246249-63-7
2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 21 h / 150 °C

2: hydrogenchloride / 4 h / 100 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / Reflux

With hydrogenchloride; toluene-4-sulfonic acid; sodium hydrogensulfite; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 1246249-64-8
2-[4-(4-acetylpiperazin-1-yl)phenyl]quinazolin-4(3H)-one

: 1246249-63-7
2-{4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]phenyl}quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / Reflux

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;