3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

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Chemical Name:3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone
CAS No.:910814-26-5
Molecular Formula:C₂₁H₂₁ClO₂S
Molecular Weight:372.916
Hs Code.:

Synonyms:3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

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Chemical Property of 3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

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Technology Process of 3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

There total 8 articles about 3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875012-78-5
1-((3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophen-1-yl)ethanone

: 107356-10-5
3-Chloro-4-hydroxy-5-methylbenzaldehyde

: 910814-26-5
3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

Guidance literature:: With sulfuric acid; In ethanol; at 20 - 50 ℃; for 1.58333h;

Reference yield:

: 498-15-7,19079-29-9
(+)-Δ³-carene

: 910814-26-5
3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

Guidance literature:: Multi-step reaction with 8 steps

1.1: ozone / methanol / -65 °C

1.2: 2 h / 20 - 35 °C

2.1: thionyl chloride / 0.5 h / 0 °C

3.1: sodium methylate / methanol / 1 h / Reflux

4.1: triphenylphosphine; tetrachloromethane / tetrachloromethane / 65 °C

5.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

5.2: 1 h / 20 °C

5.3: 1 h / 75 °C

6.1: lithium hydroxide; water / ethanol / 2 h / 75 °C

7.1: diethyl ether / 35 °C

8.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 h / 20 °C

With hydrogenchloride; tetrachloromethane; thionyl chloride; water; sodium methylate; sodium ethanolate; ozone; triphenylphosphine; lithium hydroxide; In methanol; tetrachloromethane; diethyl ether; ethanol; isopropyl alcohol; 3.1: |Dieckmann Condensation;
DOI:10.1021/jm4014373

Reference yield:

: 58930-63-5
(3¹R,3³S)-3²,3²-dimethyl-3(1,3)cyclopropyla-5-oxohexanoic acid

: 910814-26-5
3-(3-chloro-4-hydroxy-5-methyl-phenyl)-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenone

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 0.5 h / 0 °C

2.1: sodium methylate / methanol / 1 h / Reflux

3.1: triphenylphosphine; tetrachloromethane / tetrachloromethane / 65 °C

4.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

4.2: 1 h / 20 °C

4.3: 1 h / 75 °C

5.1: lithium hydroxide; water / ethanol / 2 h / 75 °C

6.1: diethyl ether / 35 °C

7.1: hydrogenchloride / ethanol; isopropyl alcohol / 20 h / 20 °C

With hydrogenchloride; tetrachloromethane; thionyl chloride; water; sodium methylate; sodium ethanolate; triphenylphosphine; lithium hydroxide; In methanol; tetrachloromethane; diethyl ether; ethanol; isopropyl alcohol; 2.1: |Dieckmann Condensation;
DOI:10.1021/jm4014373