3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

Base Information

Chemical Name:3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene
CAS No.:113748-83-7
Molecular Formula:C₂₈H₃₁NO₂
Molecular Weight:413.56
Hs Code.:

Synonyms:3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

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Chemical Property of 3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

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Technology Process of 3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

There total 5 articles about 3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28557-00-8
phenylzinc chloride

: 113748-83-7
3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 96 percent / NaOMe / dimethylformamide / 2 h / 35 °C

3: 1.) NaH / 1) DMF, room temperature; 2) 60 deg C, DMF, 30 min

With sodium methylate; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-80-4
3-methoxy-6,7-dihydro-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-83-7
3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 3 h

2: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

3: 96 percent / NaOMe / dimethylformamide / 2 h / 35 °C

4: 1.) NaH / 1) DMF, room temperature; 2) 60 deg C, DMF, 30 min

With sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-81-5
3-methoxy-6,7-dihydro-8-bromo-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-83-7
3-methoxy-6,7-dihydro-8-phenyl-9-<4-<2-(dimethylamino)ethoxy>phenyl>-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 96 percent / NaOMe / dimethylformamide / 2 h / 35 °C

3: 1.) NaH / 1) DMF, room temperature; 2) 60 deg C, DMF, 30 min

With sodium methylate; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a005