[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:659733-69-4
Molecular Formula:C₅₄H₅₃N₇O₇
Molecular Weight:912.058
Hs Code.:

[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Synonyms:[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of [(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of [(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 7 articles about [(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 163217-43-4,1391586-30-3
Fmoc-Phe-(4-N₃)-OH

: 5-aminopentanoic acid {4-[3-(3-hydroxy-3-phenylpropyl)-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]phenyl}amide

: 659733-69-4
[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With N-ethylmorpholine;; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; ethyl cyanoglyoxylate-2-oxime; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(03)00047-6

Reference yield:

: 97221-15-3
(E)-N-(4-methoxybenzylidene)-4-nitroaniline

: 659733-69-4
[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: (i-Pr)2NEt; TMSCl; TiCl₄ / CH₂Cl₂ / 15 h / -30 - -10 °C

1.2: 3.3 g / bistrimethylsilylacetamide; tetrabutylammonium fluoride / various solvent(s) / 10 h / 20 °C

2.1: 86 percent / H₂ / Pd/C / ethyl acetate / 2 h / 3750.3 Torr

3.1: 1.1 g / HCl / H₂O; tetrahydrofuran / 2 h / 20 °C

4.1: 41 percent / TOTU; hydroxyiminocyanoacetic acid ethyl ester; N-ethylmorpholine / dimethylformamide / 1 h / 20 °C

5.1: 56 percent / Et₂NH / dimethylformamide / 1 h / 20 °C

6.1: 82 percent / TOTU; hydroxyiminocyanoacetic acid ethyl ester; N-ethylmorpholine / dimethylformamide / 1 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; chloro-trimethyl-silane; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; titanium tetrachloride; diethylamine; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00047-6

Reference yield:

: 5'-(S)-tert-butyldimethylsilyloxy-5'-(phenyl) valeroyl-5-(S)-phenyloxazolidinone

: 659733-69-4
[(S)-2-(4-Azido-phenyl)-1-(4-{4-[3-((S)-3-hydroxy-3-phenyl-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-phenylcarbamoyl}-butylcarbamoyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: (i-Pr)2NEt; TMSCl; TiCl₄ / CH₂Cl₂ / 15 h / -30 - -10 °C

1.2: 3.3 g / bistrimethylsilylacetamide; tetrabutylammonium fluoride / various solvent(s) / 10 h / 20 °C

2.1: 86 percent / H₂ / Pd/C / ethyl acetate / 2 h / 3750.3 Torr

3.1: 1.1 g / HCl / H₂O; tetrahydrofuran / 2 h / 20 °C

4.1: 41 percent / TOTU; hydroxyiminocyanoacetic acid ethyl ester; N-ethylmorpholine / dimethylformamide / 1 h / 20 °C

5.1: 56 percent / Et₂NH / dimethylformamide / 1 h / 20 °C

6.1: 82 percent / TOTU; hydroxyiminocyanoacetic acid ethyl ester; N-ethylmorpholine / dimethylformamide / 1 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; chloro-trimethyl-silane; O-[(ethoxycarbonyl)cyanomethyleneamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrogen; titanium tetrachloride; diethylamine; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00047-6