2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine

Base Information

• Chemical Name: 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine
• CAS No.: 19192-40-6
• Molecular Formula: C₂₀H₂₆N₇O₁₀P
• Molecular Weight: 555.441
• Mol file: 19192-40-6.mol

Synonyms:3'-Thymidylicacid, 5'-ester with 2'-deoxyadenosine (6CI); 8: PN: US20060052323 PAGE: 23claimed sequence; TA dinucleotide; Thymidylyl-(3'®5')-2'-deoxyadenosine; dTpdA

Chemical Property of 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 248.97000
• Density: 1.99g/cm³
• LogP: -0.72130

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine

There total 17 articles about 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C57H55ClN7O15P → TpdA (19192-40-6)

Guidance literature:

DOI:10.1016/S0040-4020(01)82001-9

Reference yield:

2'-deoxy-[5']adenylic acid-(O5'-trityl-thymidin-3'-yl ester) (108480-33-7) → TpdA (19192-40-6)

Guidance literature:

With Pd-BaSO₄; ethanol; Hydrogenation;

DOI:10.1021/ja01526a050

Reference yield:

5'-O-tritylthymidine (7791-71-1) → TpdA (19192-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / und Hydrolysieren des Reaktionsproducts mit wss.NaOH

2: aqueous ethanol; palladium/BaSO₄ / Hydrogenation

With Pd-BaSO₄; ethanol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja01526a050

upstream raw materials:

5'-O-acetylthymidine

N,3'-diacetyldeoxyadenosine-5'-phosphate

2'-deoxy-[5']adenylic acid-(O^5'-trityl-thymidin-3'-yl ester)

C₅₆H₆₄N₇O₁₂PSi

Downstream raw materials:

1-methylthymine

Refernces

• 1、 Buchko,Hruska,Sadana. "Synthesis and properties of DNA oligomers containing an O4-ethylated thymine. d(e4TpA), d(Ape4T), d(Ape4TpA), and d(Tpe4TpT)". . p. 2011 - 2021. Retrieved 2007/10/02.