Technology Process of (1S,3R,4R)-4-(2-acetoxyethyl)-1-benzyloxy-3-methoxycarbonylcyclopentane
There total 9 articles about (1S,3R,4R)-4-(2-acetoxyethyl)-1-benzyloxy-3-methoxycarbonylcyclopentane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
disodium hydrogenphosphate; trifluoroacetyl peroxide;
In
dichloromethane;
for 4h;
Ambient temperature;
DOI:10.1248/cpb.33.4021
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / p-toluenesulfonic acid / CH2Cl2 / 2 h / Ambient temperature
2: 91 percent / NaBH4 / methanol / 1 h
3: 1.) sodium methylsulfinylmethide / 1.) DMSO, r.t. 1 h; 2.) DMSO, 6 h, r.t.
4: 1.) Jones reagent / 1.) acetone, < 5 degC, 1.5 h
5: 94 percent / p-toluenesulfonic acid / benzene / 3 h / Heating
6: 88 percent / sodium methoxide / toluene / 1 h, r.t; reflux, 3 h
7: 96 percent / 10percent HCl / methanol / 1.5 h / Ambient temperature
8: 87 percent / trifluoroperacetic acid, Na2HPO4 / CH2Cl2 / 4 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; disodium hydrogenphosphate; jones reagent; trifluoroacetyl peroxide; dimsylsodium; sodium methylate; toluene-4-sulfonic acid;
In
methanol; dichloromethane; toluene; benzene;
DOI:10.1248/cpb.33.4021
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium methylsulfinylmethide / 1.) DMSO, r.t. 1 h; 2.) DMSO, 6 h, r.t.
2: 1.) Jones reagent / 1.) acetone, < 5 degC, 1.5 h
3: 94 percent / p-toluenesulfonic acid / benzene / 3 h / Heating
4: 88 percent / sodium methoxide / toluene / 1 h, r.t; reflux, 3 h
5: 96 percent / 10percent HCl / methanol / 1.5 h / Ambient temperature
6: 87 percent / trifluoroperacetic acid, Na2HPO4 / CH2Cl2 / 4 h / Ambient temperature
With
hydrogenchloride; disodium hydrogenphosphate; jones reagent; trifluoroacetyl peroxide; dimsylsodium; sodium methylate; toluene-4-sulfonic acid;
In
methanol; dichloromethane; toluene; benzene;
DOI:10.1248/cpb.33.4021
