(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

Base Information

Chemical Name:(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate
CAS No.:1385068-83-6
Molecular Formula:C₂₁H₂₄N₂O₅S
Molecular Weight:416.498
Hs Code.:

Synonyms:(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

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Chemical Property of (R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

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Technology Process of (R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

There total 4 articles about (R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1385068-75-6
(R)-methyl 3-(N-methylmethylsulfonamido)-5-((1-phenylbut-3-yn-1-yl)carbamoyl)benzoate

: 1385068-83-6
(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

Guidance literature:: With quinoline; hydrogen; In methanol; at 20 ℃; for 1.5h; under 760.051 Torr;
DOI:10.1016/j.bmc.2012.05.039

Reference yield:

: 20780-53-4
(R)-Styrene oxide

: 1385068-83-6
(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 25 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 25 h / -12 - 20 °C

3: 1.3-propanedithiol; triethylamine / methanol / 47 h / 20 °C

4: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

5: quinoline; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr

With 1.3-propanedithiol; quinoline; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.039

Reference yield:

: 83816-45-9
(S)-1-phenylbut-3-yn-1-ol

: 1385068-83-6
(R)-methyl 3-(n-methylmethylsulfonamido)-5-((1-phenylbut-3-en-1-yl)carbamoyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 25 h / -12 - 20 °C

2: 1.3-propanedithiol; triethylamine / methanol / 47 h / 20 °C

3: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

4: quinoline; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr

With 1.3-propanedithiol; quinoline; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.039