(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

Base Information

Chemical Name:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone
CAS No.:234451-98-0
Molecular Formula:C₂₁H₂₃NO
Molecular Weight:305.42
Hs Code.:

Synonyms:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

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Chemical Property of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

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Technology Process of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

There total 4 articles about (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 223473-34-5
(1R,3R,4S)-3-benzoyl-2-<(1S)-phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene

: 234451-98-0
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

Guidance literature:: With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 1074-12-0
phenylglyoxal hydrate

: 234451-98-0
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂ / 0.5 h / 0 °C

2: TFA; BF₃*Et₂O / CH₂Cl₂ / 5 h / -78 °C

3: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; 1: Condensation / 2: Cycloaddition / 3: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 234451-98-0
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-phenylketone

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂ / 0.5 h / 0 °C

2: TFA; BF₃*Et₂O / CH₂Cl₂ / 5 h / -78 °C

3: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

With 4 A molecular sieve; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; 1: Condensation / 2: Cycloaddition / 3: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M