Technology Process of Iprindole
There total 7 articles about Iprindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclooctyl bromide;
With
chloro-trimethyl-silane; magnesium; ethylene dibromide; lithium chloride; zinc dibromide;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Inert atmosphere;
benzenediazonium tetrafluoroborate;
In
tetrahydrofuran;
at -60 - 25 ℃;
Inert atmosphere;
3-(Dimethylamino)propyl chloride;
Further stages;
DOI:10.1002/anie.201005319
- Guidance literature:
-
6,7,8,9,10,11-Hexahydro-5H-cycloocta[b]indole;
With
potassium tert-butylate; tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Inert atmosphere;
3-(Dimethylamino)propyl chloride;
In
N,N-dimethyl-formamide;
at 60 - 120 ℃;
for 5.5h;
Inert atmosphere;
DOI:10.1002/anie.201202971
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: indium; trifuran-2-yl-phosphane; palladium diacetate; lithium iodide / N,N-dimethyl-formamide / 5 h / 110 °C / Inert atmosphere; Molecular sieve
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 66 h / 20 °C / 7600.51 Torr / Autoclave
3.1: ethanol; potassium hydroxide / 14 h / 80 °C / Inert atmosphere
4.1: potassium tert-butylate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4.2: 5.5 h / 60 - 120 °C / Inert atmosphere
With
indium; trifuran-2-yl-phosphane; ethanol; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; palladium diacetate; tetra-(n-butyl)ammonium iodide; potassium hydroxide; lithium iodide;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/anie.201202971
