benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

Base Information

Chemical Name:benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate
CAS No.:401518-87-4
Molecular Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.535
Hs Code.:

Synonyms:benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

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Chemical Property of benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

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Technology Process of benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

There total 3 articles about benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72784-45-3
1-aminocyclopropanecarboxylic acid benzyl ester

: 2-(4-methoxy-3-methoxymethoxy-phenyl)-4-oxo-2-(2-oxo-ethyl)-butyronitrile

: 401518-87-4
benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2004.06.032

Reference yield:

: 763109-96-2
1-(3-methoxymethoxy-4-methoxyphenyl)cyclopen-3-ene-1-carbonitrile

: 401518-87-4
benzyl 1-{4-cyano-4-[4-methoxy-3-(methoxymethoxy)phenyl]piperidin-1-yl}cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / 0.42 h / -78 °C

1.2: Ph₃P / CH₂Cl₂ / 1.5 h / -78 - 20 °C

2.1: NaBH(OAc)3; AcOH / 1,2-dichloro-ethane / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; ozone; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.06.032