6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione
• CAS No.: 75997-46-5
• Molecular Formula: C₁₄H₁₂ClN₃O₄
• Molecular Weight: 321.72

Synonyms:6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione

Chemical Property of 6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione

There total 1 articles about 6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,3,6-trimethyl-5-nitrouracil (55326-07-3) + 4-chlorobenzaldehyde (104-88-1) → 6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione (75997-46-5)

Guidance literature:

With piperidine; In ethanol; for 5h; Heating;

Reference yield: 65.0%

6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione (75997-46-5) → 6-(4-Chloro-phenyl)-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione (75997-48-7)

Guidance literature:

With sodium dithionite; In formic acid; Heating;

Reference yield:

6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione (75997-46-5) → 6-(4-Chloro-phenyl)-7-hydroxy-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione (79834-62-1)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 3h; Heating;

DOI:10.1248/cpb.30.3187

upstream raw materials:

1,3,6-trimethyl-5-nitrouracil

4-chlorobenzaldehyde

Downstream raw materials:

6-(4-Chloro-phenyl)-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione

6-(4-Chloro-phenyl)-7-hydroxy-1,3-dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione

Benzoic acid 6-(4-chloro-phenyl)-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl ester

4-Chloro-benzoic acid 6-(4-chloro-phenyl)-1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl ester

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