(S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester

Base Information

• Chemical Name: (S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester
• CAS No.: 175793-20-1
• Molecular Formula: C₃₅H₃₄N₂O₇
• Molecular Weight: 594.664
• Mol file: 175793-20-1.mol

Synonyms:(S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester

Chemical Property of (S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester

There total 1 articles about (S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-3-Benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carboxylic acid → (S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester (175793-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: cyanuric fluoride, pyridine / CH₂Cl₂ / 6 h / Ambient temperature

2: N-methylmorpholine / 3 h / Ambient temperature

With 4-methyl-morpholine; pyridine; trifluoro-[1,3,5]triazine; In dichloromethane;

DOI:10.1039/cc9960000161

Reference yield: 90.0%

(S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester (175793-20-1) → (S)-3-Benzyloxy-2-[((2S,3S)-3-benzyloxy-4-oxo-azetidine-2-carbonyl)-amino]-propionic acid benzyl ester (175793-21-2)

Guidance literature:

With ammonium cerium(IV) nitrate; In dichloromethane; acetonitrile; at 0 ℃; for 1h;

DOI:10.1039/cc9960000161

Reference yield:

(S)-3-Benzyloxy-2-{[(2S,3S)-3-benzyloxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbonyl]-amino}-propionic acid benzyl ester (175793-20-1) → (2S,3S)-3-Benzyloxy-2-((S)-2-benzyloxy-1-benzyloxycarbonyl-ethylcarbamoyl)-4-oxo-azetidine-1-carboxylic acid tert-butyl ester (175793-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. (NH₄)2Ce(NO₃)6 / acetonitrile; CH₂Cl₂ / 1 h / 0 °C

2: 80 percent / DMAP / acetonitrile / 16 h / Ambient temperature

With dmap; ammonium cerium(IV) nitrate; In dichloromethane; acetonitrile;

DOI:10.1039/cc9960000161

Downstream raw materials:

(S)-3-Benzyloxy-2-[((2S,3S)-3-benzyloxy-4-oxo-azetidine-2-carbonyl)-amino]-propionic acid benzyl ester

(2S,3S)-3-Benzyloxy-2-((S)-2-benzyloxy-1-benzyloxycarbonyl-ethylcarbamoyl)-4-oxo-azetidine-1-carboxylic acid tert-butyl ester

(S)-3-Benzyloxy-2-((2S,3S)-3-benzyloxy-2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-propionic acid benzyl ester