1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Base Information

Chemical Name:1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea
CAS No.:1446483-40-4
Molecular Formula:C₂₄H₂₆F₃N₇O₂S
Molecular Weight:533.577
Hs Code.:

Synonyms:1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

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Chemical Property of 1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

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Technology Process of 1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

There total 7 articles about 1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 1446483-21-1
ethyl 2-(4-((2-(4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)thiazol-4-yl)methyl)piperazin-1-yl)acetate

: 1446483-40-4
1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: With hydrazine hydrate; In ethanol; at 50 ℃; for 48h;
DOI:10.3390/molecules18032904

Reference yield:

: 873-74-5
4-Aminobenzonitrile

: 1446483-40-4
1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / ethanol

1.2: 24 h / 80 °C

2.1: tetrahydrofuran / 20 °C

3.1: magnesium chloride; sodium hydrogensulfide / N,N-dimethyl-formamide / 20 °C

4.1: tetrahydrofuran / 7 h / 50 °C

5.1: ethanol / 2 h / 20 °C

6.1: sodium iodide; potassium carbonate / ethanol / 2 h / 50 °C

7.1: hydrazine hydrate / ethanol / 48 h / 50 °C

With hydrogenchloride; sodium hydrogensulfide; potassium carbonate; hydrazine hydrate; sodium iodide; magnesium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules18032904

Reference yield:

: 40465-45-0
p-cyanophenyl isocyanate

: 1446483-40-4
1-(4-(trifluoromethyl)phenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 20 °C

2: magnesium chloride; sodium hydrogensulfide / N,N-dimethyl-formamide / 20 °C

3: tetrahydrofuran / 7 h / 50 °C

4: ethanol / 2 h / 20 °C

5: sodium iodide; potassium carbonate / ethanol / 2 h / 50 °C

6: hydrazine hydrate / ethanol / 48 h / 50 °C

With sodium hydrogensulfide; potassium carbonate; hydrazine hydrate; sodium iodide; magnesium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules18032904