1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester
CAS No.:68682-80-4
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

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Chemical Property of 1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

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Technology Process of 1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

There total 7 articles about 1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₁NO₃

: 68682-80-4
1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; ethyl acetate; at 0 ℃; Inert atmosphere;
DOI:10.1039/c7ob01714f

Reference yield:

: 16880-41-4
ethyl 1-benzyl-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate

: 68682-80-4
1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyrrolidine / dichloromethane / 25 °C / Inert atmosphere

2: sodium tetrahydroborate / ethyl acetate; ethanol / 0 °C / Inert atmosphere

With pyrrolidine; sodium tetrahydroborate; In ethanol; dichloromethane; ethyl acetate; 1: |Knoevenagel Condensation;
DOI:10.1039/c7ob01714f

Reference yield:

: 90832-90-9
ethyl 2-methyl-5-oxo-4,5-dihydrofuran-3-carboxylate

: 68682-80-4
1,4-dibenzyl-2-methyl-5-oxo-4,5-dihydro-pyrrole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl hydrogen phosphate / toluene / 12 h / 125 °C / Inert atmosphere

2: pyrrolidine / dichloromethane / 25 °C / Inert atmosphere

3: sodium tetrahydroborate / ethyl acetate; ethanol / 0 °C / Inert atmosphere

With pyrrolidine; sodium tetrahydroborate; diphenyl hydrogen phosphate; In ethanol; dichloromethane; ethyl acetate; toluene; 2: |Knoevenagel Condensation;
DOI:10.1039/c7ob01714f