4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Base Information

Chemical Name:4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide
CAS No.:1244968-20-4
Molecular Formula:C₂₆H₃₃N₅O₄S
Molecular Weight:511.645
Hs Code.:

Synonyms:4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

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Chemical Property of 4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

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Technology Process of 4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

There total 2 articles about 4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 41507-35-1
3-thiophene carboxylic acid chloride

: 1244968-56-6
N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

: 1244968-20-4
4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; chloroform; at 20 ℃;

Reference yield:

: 1175959-17-7
C₁₆H₂₃N₃O₂

: 1244968-20-4
4-((thiophen-3-yl)carbonyl)-N-(4-(4-morpholin-4-ylcarbonylpiperidin-1-yl)phenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.5 h / -30 °C

1.2: 17 h / 20 - 60 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 18 h / 20 °C

3.1: triethylamine / chloroform; tetrahydrofuran / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform;