4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

Base Information

Chemical Name:4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide
CAS No.:1398045-41-4
Molecular Formula:C₂₅H₂₆ClFN₄O₂S
Molecular Weight:501.024
Hs Code.:

Synonyms:4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

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Chemical Property of 4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

There total 8 articles about 4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1272719-26-2
C₈H₂ClFN₂S

: 1398047-56-7
C₁₇H₂₅N₃O

: 1398045-41-4
4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: C₈H₂ClFN₂S; C₁₇H₂₅N₃O; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; methanol; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 2106-04-9
3-chloro-2-fluoroaniline

: 1398045-41-4
4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: pyridine / 0.83 h / 20 °C

2.2: pH 7 / Cooling with ice

3.1: N,N-dimethyl-formamide / 145 °C / Inert atmosphere

4.1: hydrogenchloride / ethanol; water / 1 h / Reflux

5.1: water; tetrahydrofuran / 1 h / 20 °C

6.1: N,N-dimethyl-formamide / 20 °C

6.2: 2 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; pyridine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 115843-99-7
4-bromo-3-chloro-2-fluoroaniline

: 1398045-41-4
4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 0.83 h / 20 °C

1.2: pH 7 / Cooling with ice

2.1: N,N-dimethyl-formamide / 145 °C / Inert atmosphere

3.1: hydrogenchloride / ethanol; water / 1 h / Reflux

4.1: water; tetrahydrofuran / 1 h / 20 °C

5.1: N,N-dimethyl-formamide / 20 °C

5.2: 2 h / Reflux

With hydrogenchloride; pyridine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;